Background::The association of lipids and cancer has varied greatly among different cancer types, lipid components and study populations. This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.Methods::In the "Endoscopic Screening for Esophageal Cancer in China" (ESECC) trial, serum samples were collected and tested for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol at the time of subject enrollment. Cases were defined as malignant esophageal lesions identified by baseline endoscopic examination or by follow-up to May 31, 2018. Controls were randomly selected using incidence density sampling in the same cohort. Conditional logistic models were applied to identify the association of serum lipids and the risk of malignant esophageal lesions. Effect modification was evaluated by testing interaction terms of the factor under assessment and these serum lipid

作者：Wang Min-Min；Guo Chuan-Hai；Li Feng-Lei；Xu Rui-Ping；Liu Zhen；Pan Ya-Qi；Liu Fang-Fang；Liu Ying；Cai Hong；Liu Meng-Fei；He Zhong-Hu；Ke Yang

来源：中华医学杂志英文版 2021 年 134卷 9期