OBJECTIVETo assess the efficacy of captopril on mortality and morbidity after acute myocardial infarction (AMI).METHODSA total of 14,962 patients entering 650 hospitals from 30 provinces and autonomous regions of China up to 36 hours (mean 16.6±10.2 hours) after the onset of suspected acute myocardial infarction (MI) with no clear contraindications or indications to the study treatments (in particular, no persistent hypotension or hypovolemia due to long-term use of large dose of diuretics) were randomized to use either 4 weeks of oral captopril (6.25 mg initial dose, 12.5 mg 2 hours later, and then 12.5 mg three times daily) or matching placebo.RESULTSCaptopril was associated with a non-significant reduction in 4-week mortality (9.12

来源：CHINESE MEDICAL JOURNAL 1997 年 110卷 11期