Background::Zinc finger and BTB domain-containing protein 46 ( Zbtb46) is a transcription factor identified in classical dendritic cells, and maintains dendritic cell quiescence in a steady state. Zbtb46 has been reported to be a negative indicator of acute myeloid leukemia (AML). We found that Zbtb46 was expressed at a relatively higher level in hematopoietic stem and progenitor cells (HSPCs) compared to mature cells, and higher in AML cells compared to normal bone marrow (BM) cells. However, the role of Zbtb46 in HSPCs and AML cells remains unclear. Therefore, we sought to elucidate the effect of Zbtb46 in normal hematopoiesis and AML cells. Methods::We generated Zbtb46fl/fl and Zbtb46fl/flMx1-Cre mice. The deletion of Zbtb46 in Zbtb46fl/flMx1-Cre mice was induced by intraperitoneal injection of double-stranded poly (I). poly (C) (poly(I:C)), and referred as Zbtb46 cKO. After confirming the deletion of Zbtb46, the frequency and

作者：Liu Yuan-Yuan；Xiao Fei-Fei；Yang Bi-Jie；Li Xi；Xu Shuang-Nian；Chen Zhi-Wei；Li Ping；Huang Yong-Xiu；Fu Xue-Mei；Huang Xing-Qin；Zheng Guang-Ling；Chen Jie-Ping；Hou Yu

来源：中华医学杂志英文版 2020 年 133卷 14期